The long read sequencing market in North America is expected to grow from US$ 570.24 million in 2021 to US$ 2,254.97 million by 2028; it is estimated to grow at a CAGR of 21.7% from 2021 to 2028.

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North America Long Read Sequencing Market Overview

Five years ago, genomic sequencing was primarily confined to research settings. Today, it is increasingly integrated into clinical practice, and over the next five years, it is projected that genomic data from more than 60 million patients will be generated within healthcare systems. This shift marks a significant transition toward the clinical adoption of genomic sequencing, supported by substantial government investments totaling over US$4 billion across at least 14 countries. These national genomic medicine initiatives are driving transformative change in real-world settings by addressing implementation barriers and generating critical evidence to support broader adoption—factors that are fueling market growth globally.

North America Long Read Sequencing Market Introduction –

North America leads the global long read sequencing market, with the United States holding the largest share, followed by Canada. Market growth in the region is driven by a surge in demand for gene synthesis technologies from biopharmaceutical and biotechnology companies, the presence of key industry players, and intensive R&D efforts across academic and research institutions.

The increasing adoption of advanced genomic technologies in healthcare, combined with both public and private sector initiatives to promote precision medicine, are contributing significantly to the market’s expansion. Additionally, robust financial support from government bodies and private organizations for genomic research continues to drive strong revenue generation in this sector.

Impact of COVID-19 on North America Long Read Sequencing Market Growth

The COVID-19 pandemic had a profound impact on the healthcare sector across North America, particularly in the United States, which recorded one of the highest numbers of cases globally. The crisis underscored the need for enhanced genomic surveillance and catalyzed innovation in sequencing technologies.

In response, scientists across the region collaborated to generate and share genomic sequence data for improved disease diagnosis, surveillance, and control. The U.S. has since ramped up efforts to track virus mutations through genomic sequencing, particularly as new variants continue to emerge. At one point, the country ranked 43rd globally in genome sequencing efforts, having sequenced only 3% of COVID-19 samples according to the GISAID Initiative, a global sequencing data platform.

Efforts to close this gap were significant. For instance, in April 2020, Genome Canada launched the Canadian COVID Genomics Network (CanCOGeN) with $40 million in funding. This national initiative brought together Genome Canada, six regional Genome Centers, CGEn sequencing facilities, public health laboratories, universities, hospitals, and private sector stakeholders to scale up genome-based COVID-19 research efforts both domestically and internationally.

Similarly, in the U.S., Pacific Biosciences of California, Inc., in collaboration with Labcorp, developed a production-scale sequencing assay using the Sequel II system to sequence the complete genome of thousands of SARS-CoV-2 virus samples from positive patients.

These pandemic-driven innovations and investments are expected to significantly boost future demand for long read sequencing technologies across North America, solidifying the region’s leadership in the global genomics market.

North America Long Read Sequencing Market Segmentation

North America Long Read Sequencing Market -By Technology

• Single-Molecule Real-Time Sequencing (SMRT)
• Nanopore Sequencing
• Loop Genomics Long-Read Sequencing

North America Long Read Sequencing Market -By Product

• Instruments
• Consumables
• Services

North America Long Read Sequencing Market -By Application

• Identification and fine mapping of structural variation
• Tandem Repeat Sequencing
• Pseudogene discrimination
• Resolving allele phasing
• Reproductive genomics
• Cancer
• Viral and Microbial Sequencing
• Others

North America Long Read Sequencing Market -By Workflow

• Pre-sequencing
• Sequencing
• Data Analysis

North America Long Read Sequencing Market -By End User

• Academic Research Institutes
• Hospitals and Clinics
• Pharma and Biotechnology Companies

North America Long Read Sequencing Market -By Country

• US
• Canada
• Mexico

North America Long Read Sequencing Market -Company Profiles

• Bionano Genomics
• F. HOFFMANN-LA ROCHE LTD.
• Illumina, Inc.
• Oxford Nanopore Technologies
• Pacific Biosciences of California, Inc.
• PerkinElmer, Inc.
• Quantapore, Inc.

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Author’s Bio:

Suryakant Gadekar

Senior Market Research Expert at Business Market Insights